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260 大学院医歯学総合研究科(歯) = Graduate School of Medical and Dental Sciences (Dental) >
60 博士学位論文 = Doctoral Thesis >
10 博士学位論文 >


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Title :Relationships between IL-6 gene polymorphism, low BMD and periodontitis in postmenopausal women
Title alternative :IL-6 遺伝子多型が歯周炎と Low BMD に与える影響
Authors :Hanai, Yuki
Publisher :新潟大学
Issue Date :23-Mar-2015
Description :学位の種類: 博士(歯学). 報告番号: 甲第4009号. 学位記番号: 新大院博(歯)甲第322号. 学位授与年月日: 平成27年3月23日
Archives of Oral Biology. 2015, 60(4), 533-539.
Abstract :Objective: IL-6 plays critical roles in bone resorption and the pathogenesis of periodontitis in both inflammation and alveolar bone loss. A negative correlation was observed between periodontitis and truncal bone mineral density (BMD) in postmenopausal women. The C allele carriers of a genetic polymorphism IL-6-572G/C have higher levels of serum IL-6 compared to G allele carriers. We investigated the possible effect of IL-6-572G/C polymorphism on the relationship between low BMD and periodontitis in postmenopausal women. Subjects and methods: A total of 300 postmenopausal Japanese women who lived in Yokogoshi area of Niigata City, Japan, participated in this study. Genomic DNA was extracted from peripheral blood. The IL-6-572G/C genotypes were determined by the restriction fragment length polymorphism method. Bone mineral density (BMD) of right femoral neck and serum bone metabolism markers were measured. Low BMD was defined to have the BMD < 80% of the mean for young adults. Periodontal parameters at two sites per tooth were measured. Results: Serum osteocalcin levels were significantly lower in the IL-6-572G/G genotype (p = 0.025). In the -572G allele non-carriers, percentages of PPD > 4 mm sites were significantly higher in low BMD group compared with the healthy control group (p = 0.021). Logistic regression analysis revealed low BMD to be associated with periodontitis (Odds ratio = 1.736, p = 0.027) after adjusted with IL-6-572G carriage, age, serum albumin level. Conclusions: IL-6-572G/C polymorphism was not an independent risk factor of low BMD or periodontitis, but may affect the relationship between the two diseases in postmenopausal Japanese women.
Keywords :IL-6
Type Local :学位論文
Language :eng
Format :application/pdf
URI :http://hdl.handle.net/10191/32178
fullTextURL :http://dspace.lib.niigata-u.ac.jp/dspace/bitstream/10191/32178/1/h26ndk322_a.pdf
DOI :info:doi/10.1016/j.archoralbio.2014.12.005
Rights :Copyright(C) 2015 Elsevier
Grant id :13101甲第4009号
Date of granted :2015-03-23
Degree name :博士(歯学)
Grantor :新潟大学
Appears in Collections:10 博士学位論文

Please use this identifier to cite or link to this item: http://hdl.handle.net/10191/32178