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新潟大学学術リポジトリ Nuar >
250 大学院医歯学総合研究科（医） = Graduate School of Medical and Dental Sciences (Medical) >
20 紀要 = Departmental Bulletin Paper >
01 Acta medica et biologica >
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| Title | : | Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function |
| Authors | : | Nagai, Shingo
Urayama, Katsuhiro
Higuchi, Hiroshi |
| Publisher | : | 新潟大学医学部 |
| Issue Date | : | Dec-2006 |
| Journal Title | : | Acta medica et biologica |
| Volume | : | 54 |
| Issue | : | 4 |
| Start Page | : | 103 |
| End Page | : | 108 |
| ISSN | : | 0567-7734 |
| Description | : | Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state. |
| Keywords | : | anxiolytic
tandospirone
mental stress
color word conflict test
heart rate
blood pressure |
| Type Local | : | 紀要論文 |
| Language | : | eng |
| URI | : | http://hdl.handle.net/10191/5235 |
| fullTextURL | : | http://dspace.lib.niigata-u.ac.jp/dspace/bitstream/10191/5235/1/17_0008.pdf |
| Appears in Collections | : | 01 Acta medica et biologica
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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10191/5235
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